grimmsapothecary
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Addition to Methylation Protocol
🕑 Added 2021-08-01 20:38:23 +0000 UTCSo I had mentioned there was an important to address prior to addressing methylation, and that was nutritional repletion across the board, ATP development, and redox/detox capacity.
So aside from red Light from direct sunlight exposure, which induces ATP production without having to take in food energy or nutrition, the focus of the diet should be seafood, shellfish/bivalves, organs, red meats, eggs, and quality dairy/cheese/butters. You may include properly prepared leafy green vegetables, sprouts, tubers, fruits, and magnesium salt soaked seeds/nuts if you tolerate them, but the prior mentioned foods are most significantly for nutritional repletion today.
You will want to address this issue in the following order:
- support the transsulferation pathway with vitamin B1 (thiamine) and molybdenum
- support glutathione production with sufficient vitamin B6 (Pyroxidine/P5P), glycine, cysteine/NAC, glutamine, and selenium
- THEN you can begin to support the methionine/methylation cycle with vitamin B6 (pyroxidine/P5P), vitamin B2 (riboflavin), magnesium, choline and/or betaine/Trimethylglycine, vitamin B12s (methylcobalamin/Adenosylcobalamin), and maybe additional zinc, potassium, and methionine
- THEN support the folate cycle with Folinic acid + riboflavin + sunlight exposure or Methylfolate (5-MTHF), and serine
- and hopefully you’re already recycling tetrahydrobiopterin (BH4) with vitamin C from whole food sources
The only nutritional factor that isn’t included with the suggestions above is molybdenum, which is primarily found in beans. the best preparation process for beans is with a pressure cooker which cuts the soak time down to 24 hrs, but soak for 48-72 hrs otherwise. The Native American Ancestors (search Native American Three Sisters) had a 1-2 week preparation process to make these foods digestible and the nutrition bioavailable, which included soaking/sprouting, fermenting, THEN cooking, and even refrying for the beans specifically. A supplement is perfectly fine if you do not tolerate the beans regardless of preparation process, though the soaking should make them far more digestible for you.
Additional notes:
Selenium improves GSH levels
Vitamin B2 (Riboflavin) improves GSSG-GSH recycling)
Vitamin B3 (Niacin) increases NADPH
Ordinary vitamin B1 (Thiamine) increases NAPH via the pentose phosphate pathway
NAC/cysteine preferably with glycine, and even glutathione itself also improves GSH status
