Misha Batin
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What should be done to radically prolong life?
🕑 Added 2023-08-05 06:40:07 +0000 UTCLet's start with this:
[Tasks vary in scale]
1. Experimental work to research aging mechanisms. This point, like many others, implies the work of tens, if not hundreds of thousands of researchers.
2. Creating databases. Implementing projects such as First Approval.
3. Summaries, reviews, analytics, selection of promising directions.
4. Training AI for discovering new drugs and targets.
5. Experiments on extending the lifespan of animals.
6. Preclinical studies.
7. Clinical studies.
8. Creating panels and validating aging biomarkers. Clinical studies of the same.
9. Automated lifespan experiment equipment.
10. Scientific organizational work, holding conferences.
11. Writing grant applications, reports.
12. Creating longevity biotech startups.
13. Popular science articles about aging.
14. Creating websites about aging.
15. Books about aging and longevity.
16. Collection and analysis of human health data.
17. Development of recommendation systems.
18. Implementation of personalized medicine standards.
19. Healthy lifestyle organization.
20. Improving the healthcare system.
21. Increasing patient awareness, compliance, access to the best treatment.
22. Creating apps for health monitoring and improvement.
23. Developing gadgets.
24. Miniaturization and enhancement of diagnostic systems. Organizing data flow.
25. Developing new methods of manipulating the living.
26. Everything else about regenerative medicine, organ and tissue replacement.
27. Everything else about the evolutionary-comparative biology of aging. New model animals.
28. Chemoinformatics, quantum chemistry, synthesis of new compounds, quantum chemistry.
29. Creating next-generation antibodies.
30. Creating nanorobots.
31. Human cloning.
32. Promoting futurism, lectures, projects, creating a positive image of the future.
33. Interaction with government agencies, conducting roundtables and consultations.
34. Lobbying research programs.
35. Social media, Reddit, 𝕏.
36. Organizing online forums.
37. Conducting study circles, lectures, journal clubs.
38. University programs in the field of Longevity.
39. Schools, accelerators, workcamps for biotech entrepreneurs.
40. IPO of biotech longevity startups.
41. Developing cryoprotectants.
42. Promoting cryonics by all the above and below-mentioned means.
43. Creating YouTube channels.
44. Creating movies about life extension.
45. Interaction with bloggers, journalists, opinion leaders.
46. Incorporating celebrities in the fight against aging.
47. Exhibitions, creating works of art, art-science.
48. Creating public organizations, patient organizations.
49. Flash mobs, activism, crowdfunding.
50. Open science, crowdsourcing, experimental films.
51. Creation of scientific journals
52. Mechanomedicine, mitochondrial medicine, immune system rejuvenation, genome stability enhancement, lipid metabolism – identifying several vast areas that develop separately from longevity
53. Combating fibrosis, vascular rejuvenation, inflammation research
54. Combatting skin aging
55. Integration of knowledge about aging and pathophysiological processes
56. Research on the relationship between aging and cancer, vaccinations against tumor diseases
57. Microbiome research
58. Creation of living systems as therapeutic and diagnostic agents
59. Development of genetic engineering
60. Development and application of network theory
61. Construction of aging models
62. Head transplantation
63. Brain tissue transplantation
64. Inter-laboratory exchange service for life-extending therapies
65. Political organizations, interaction with politicians, including longevity ideas in election programs
66. Lobbying, drafting legislation
67. Addressing objections through all mentioned means
68. Engaging new players in aging, creating an attractor
69. Creation of longevity territories
70. Network state, crypto longevity
71. Digital immortality: propaganda, creating intellectual avatars, self-description, services, startups. Smart wills
72.Sociological, anthropological, psychological studies of aging, attitudes towards death, and readiness to act
73. Use of network theory in societal analysis and finding the best impact
74. Gamification of the fight against aging
75. Interaction with friendly organizations, cooperation agreements, joint events
76. Propagating transhumanism. Books, films, exhibitions. Philosophical justification of transhumanism
77. Transhumanism discussion with long-termism, effective altruism, and new leftists
78. Merch, clothing, souvenirs, fashion
79. Digital fitness
80. Nutrition research
81. Assessment of the contribution of various molecular mechanisms of aging. Finding the best combination of therapeutic agents against aging
82. Creation of strategies, plans in all areas. Analysis of the situation and possibilities
83. Creation of questionnaires, instructions, rules for those wishing to participate in the Longevity movement. Informatization of the very fight for extending human life
84. Research on the aging and rejuvenation of domestic animals
85. Writing articles, books about non-acceptance of death. Filming
86. Building a Cochrane-like institute for Longevity. Fighting the reproducibility crisis
87. Rechecking key articles in the field of longevity
88. Searching for new forms of organizing science, motivating scientists, and presenting results
89. Formulating exciting scientific and social tasks related to life extension. Organization of awards, contests, competitions. Life extension olympiad
90. Synthesis of material, establishing connections between research, cross-disciplinary projects
91. Large longitudinal studies with extensive data collection
92. Creating something akin to the UK Biobank in all developed countries
93. Creating an atmosphere of moral encouragement for players in the field of Longevity. Alerting the public to the competition in the search for life extension methods
94. Identifying and solving existential risk problems
95. Radiobiology, astrobiology, as ways to find useful solutions in parallel fields
96. Advocacy and lobbying for evidence-based policies. Rational influence on society, application of the scientific method to solve the problem of funding research
97. Formation of radically-minded minorities. Longevity leadership school
98. Collection and presentation of evidence for the realism of the idea of human life extension
99. Special support for bold experiments, original ideas, fundamentally new therapies
100. Creation of currently unknown transhumanist products
All of this is being done, but either insufficiently, blatantly little, or very insignificantly, or only in projects.
Why? I have a definitive answer.
People don't want to live strongly enough.
Even those involved in the industry want to, but not enough. Not enough to go all-in against death.
This and no other problem is what we must solve. The rest will take care of itself without us.
Looking at these, literally, a million projects, we must choose. Just one project. We'll choose a second when we have more resources.
Surprisingly, such a project doesn't lie in the field of aging research. It must be related to the desire to live.
First and foremost, we need to spread the idea: death is extremely bad. The rest will happen automatically.
Proving the badness of death is also a complex activity. But without such projects, we will stagnate.
